Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC055
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-21 09:59
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment carboma 3x1 madopar hbs 2x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 32 individuals with a value less than 0.64 were subsequently diagnosed with PD. That is, 76.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.64 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 31, 'TN': 25, 'TP': 11, 'FP': 5}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 18, 'TN': 13, 'TP': 24, 'FP': 17}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 26, 'TN': 21, 'TP': 16, 'FP': 9}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 4, 'TP': 37, 'FP': 26}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 10.632
timePerCircleCoV 0.0889033
timePerCircleSlope 0.00985019
meanError 2.09162
tremorFreq 6.64062
tremorRelPower 20.4688
tremorGyroAmpMean 0.0259254
tremorGyroAmpSlope 0.000645395
tremorGyroAmpCoV 0.443867
tremorCoordAmpMean 0.0482893
tremorCoordAmpSlope 0.00342268
tremorCoordAmpCoV 0.488275
tremorAccAmpMean 0.0387371
tremorAccAmpSlope 0.0022047
tremorAccAmpCoV 0.537753
tremorPcRelVar 0.717053
tremorPcX 0.790999
tremorPcY -0.611817

Circle Segment 1

Duration 10.36 s, Accuracy Estimate 1.767 (lower is better)

Circle Segment 2

Duration 11.64 s, Accuracy Estimate 1.975 (lower is better)

Circle Segment 3

Duration 9.52 s, Accuracy Estimate 2.015 (lower is better)

Circle Segment 4

Duration 10.04 s, Accuracy Estimate 2.099 (lower is better)

Circle Segment 5

Duration 9.88 s, Accuracy Estimate 1.953 (lower is better)

Circle Segment 6

Duration 10.56 s, Accuracy Estimate 1.757 (lower is better)

Circle Segment 7

Duration 10.44 s, Accuracy Estimate 2.721 (lower is better)

Circle Segment 8

Duration 10.4 s, Accuracy Estimate 2.205 (lower is better)

Circle Segment 9

Duration 12.8 s, Accuracy Estimate 1.621 (lower is better)

Circle Segment 10

Duration 10.68 s, Accuracy Estimate 2.804 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 39.12
timePerSpiralCoV 0.0629146
timePerSpiralSlope -0.0157172
meanError 2.35094
tremorFreq 7.71484
tremorRelPower 20.8606
tremorGyroAmpMean 0.0290153
tremorGyroAmpSlope 0.00315475
tremorGyroAmpCoV 0.43218
tremorCoordAmpMean 0.0611322
tremorCoordAmpSlope 0.000750993
tremorCoordAmpCoV 0.895354
tremorAccAmpMean 0.0723177
tremorAccAmpSlope 0.000890553
tremorAccAmpCoV 0.164856
tremorPcRelVar 0.590848
tremorPcX -0.76953
tremorPcY 0.638611

Spiral Segment 1

Duration 38.8 s, Accuracy Estimate 2.572 (lower is better)

Spiral Segment 2

Duration 42.24 s, Accuracy Estimate 2.233 (lower is better)

Spiral Segment 3

Duration 38.76 s, Accuracy Estimate 2.416 (lower is better)

Spiral Segment 4

Duration 38.56 s, Accuracy Estimate 2.404 (lower is better)

Spiral Segment 5

Duration 41.2 s, Accuracy Estimate 2.237 (lower is better)

Spiral Segment 6

Duration 35.16 s, Accuracy Estimate 2.244 (lower is better)

Elel

eDurationMean 0.514884
eDurationStd 0.0937924
eDurationStdnorm 0.182162
eDurationMedian 0.51
eDurationQuartdelta 0.12
eDurationQuartdeltanorm 0.235294
eDurationKurt 3.97838
eDurationTrenddiff -0.07
eDurationTrendratio 0.87156
eWidthMean 3.29505
eWidthStd 1.24476
eWidthStdnorm 0.377766
eWidthMedian 3.159
eWidthQuartdelta 1.49175
eWidthQuartdeltanorm 0.472222
eWidthKurt 4.2337
eWidthTrenddiff -0.936
eWidthTrendratio 0.741935
eHeightMean 6.98463
eHeightStd 1.64783
eHeightStdnorm 0.235922
eHeightMedian 6.786
eHeightQuartdelta 1.84275
eHeightQuartdeltanorm 0.271552
eHeightKurt 4.74334
eHeightTrenddiff -0.936
eHeightTrendratio 0.868852
eAspectMean 0.475297
eAspectStd 0.143934
eAspectStdnorm 0.302829
eAspectMedian 0.487805
eAspectQuartdelta 0.200266
eAspectQuartdeltanorm 0.410546
eAspectKurt 3.45315
eAspectTrenddiff -0.0955948
eAspectTrendratio 0.816561
eSlantMean 0.0932794
eSlantStd 0.163055
eSlantStdnorm 1.74803
eSlantMedian 0.0877193
eSlantQuartdelta 0.157977
eSlantQuartdeltanorm 1.80094
eSlantKurt 3.22619
eSlantTrenddiff -0.0727899
eRtopMean 0.813097
eRtopStd 0.146383
eRtopStdnorm 0.180031
eRtopMedian 0.864865
eRtopQuartdelta 0.135991
eRtopQuartdeltanorm 0.15724
eRtopKurt 3.43589
eRtopTrenddiff 0.0728291
eRbotMean 0.681303
eRbotStd 0.471876
eRbotStdnorm 0.692607
eRbotMedian 0.59375
eRbotQuartdelta 0.370854
eRbotQuartdeltanorm 0.624596
eRbotKurt 19.1546
eRbotTrenddiff 0.225617
eRrightMean 0.919629
eRrightStd 0.0719835
eRrightStdnorm 0.0782745
eRrightMedian 0.938462
eRrightQuartdelta 0.0502141
eRrightQuartdeltanorm 0.0535069
eRrightKurt 4.35733
eRrightTrenddiff -0.00153846
eRleftMean 0.34712
eRleftStd 0.15091
eRleftStdnorm 0.434749
eRleftMedian 0.343284
eRleftQuartdelta 0.183711
eRleftQuartdeltanorm 0.535159
eRleftKurt 5.94573
eRleftTrenddiff -0.0283688
lDurationMean 0.834333
lDurationStd 0.19008
lDurationStdnorm 0.227822
lDurationMedian 0.81
lDurationQuartdelta 0.215
lDurationQuartdeltanorm 0.265432
lDurationKurt 4.31563
lDurationTrenddiff -0.1625
lDurationTrendratio 0.822888
lWidthMean 7.4724
lWidthStd 2.57323
lWidthStdnorm 0.344364
lWidthMedian 7.722
lWidthQuartdelta 3.77325
lWidthQuartdeltanorm 0.488636
lWidthKurt 2.70229
lWidthTrenddiff -2.8665
lWidthTrendratio 0.657343
lHeightMean 15.0904
lHeightStd 3.60726
lHeightStdnorm 0.239043
lHeightMedian 14.274
lHeightQuartdelta 4.41675
lHeightQuartdeltanorm 0.309426
lHeightKurt 6.48916
lHeightTrenddiff -2.7495
lHeightTrendratio 0.830935
lAspectMean 0.493103
lAspectStd 0.133637
lAspectStdnorm 0.271013
lAspectMedian 0.489796
lAspectQuartdelta 0.166288
lAspectQuartdeltanorm 0.339504
lAspectKurt 3.62554
lAspectTrenddiff -0.119369
lAspectTrendratio 0.774486
lSlantMean 0.301969
lSlantStd 0.145156
lSlantStdnorm 0.480698
lSlantMedian 0.311475
lSlantQuartdelta 0.166836
lSlantQuartdeltanorm 0.535631
lSlantKurt 6.20346
lSlantTrenddiff -0.112975
lRtopMean 0.909629
lRtopStd 0.101248
lRtopStdnorm 0.111307
lRtopMedian 0.953488
lRtopQuartdelta 0.100239
lRtopQuartdeltanorm 0.105129
lRtopKurt 4.3036
lRtopTrenddiff 0.0244209
lRbotMean 0.310306
lRbotStd 0.217802
lRbotStdnorm 0.701894
lRbotMedian 0.261364
lRbotQuartdelta 0.227276
lRbotQuartdeltanorm 0.869577
lRbotKurt 16.8873
lRbotTrenddiff 0.135124
lRrightMean 0.95591
lRrightStd 0.0479892
lRrightStdnorm 0.0502026
lRrightMedian 0.978417
lRrightQuartdelta 0.0533885
lRrightQuartdeltanorm 0.0545662
lRrightKurt 3.96192
lRrightTrenddiff 0.00147248
lRleftMean 0.17417
lRleftStd 0.0867857
lRleftStdnorm 0.498283
lRleftMedian 0.154696
lRleftQuartdelta 0.12107
lRleftQuartdeltanorm 0.78263
lRleftKurt 2.84357
lRleftTrenddiff 0.0134947

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

Elel Segment 16

Elel Segment 17

FITTS Short Modified

meanTouchScore 0.896848
sumTouchScores 17.0401
meanMovementTime 0.980556
numTouches 19
undershootPercentage 5.26316
overshootPercentage 10.5263

FITTS Long Modified

meanTouchScore 0.731789
sumTouchScores 10.9768
meanMovementTime 1.41821
numTouches 15
undershootPercentage 13.3333
overshootPercentage 13.3333

ZigZag

numZigzags 5
timePerZigzagMean 13.112
timePerZigzagCoV 0.321154
timePerZigzagSlope 0.124466
meanError 2.84876
tremorFreq 5.66406
tremorRelPower 17.1297
tremorGyroAmpMean 0.144217
tremorGyroAmpSlope -0.00583471
tremorGyroAmpCoV 0.590945
tremorCoordAmpMean 0.176879
tremorCoordAmpSlope -0.00888686
tremorCoordAmpCoV 0.406189
tremorAccAmpMean 0.161929
tremorAccAmpSlope -0.00646231
tremorAccAmpCoV 0.339715
tremorPcRelVar 0.763977
tremorPcX 0.350208
tremorPcY 0.936672

ZigZag Segment 1

Duration 8.04 s, Accuracy Estimate 3.165 (lower is better)

ZigZag Segment 2

Duration 10.0 s, Accuracy Estimate 3.062 (lower is better)

ZigZag Segment 3

Duration 18.28 s, Accuracy Estimate 2.383 (lower is better)

ZigZag Segment 4

Duration 16.08 s, Accuracy Estimate 2.904 (lower is better)

ZigZag Segment 5

Duration 13.16 s, Accuracy Estimate 2.729 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 13.832
timePerZigzagCoV 0.11588
timePerZigzagSlope -0.0164835
zigzagHeightMean 41.8679
zigzagHeightCoV 0.149545
zigzagHeightSlope -0.0850775
meanError 0.0870817
tremorFreq 6.73828
tremorRelPower 22.8515
tremorGyroAmpMean 0.0318696
tremorGyroAmpSlope -0.00318039
tremorGyroAmpCoV 0.340931
tremorCoordAmpMean 0.0816573
tremorCoordAmpSlope -0.00336589
tremorCoordAmpCoV 0.418671
tremorAccAmpMean 0.0533448
tremorAccAmpSlope -0.00264041
tremorAccAmpCoV 0.328569
tremorPcRelVar 0.868885
tremorPcX -0.575266
tremorPcY -0.817966

ZigZag Offset Segment 1

Duration 13.08 s, Accuracy Estimate 0.065 (lower is better)

ZigZag Offset Segment 2

Duration 14.88 s, Accuracy Estimate 0.088 (lower is better)

ZigZag Offset Segment 3

Duration 15.92 s, Accuracy Estimate 0.093 (lower is better)

ZigZag Offset Segment 4

Duration 11.8 s, Accuracy Estimate 0.053 (lower is better)

ZigZag Offset Segment 5

Duration 13.48 s, Accuracy Estimate 0.136 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.72}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.64}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7120929025935443}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8491670201175172}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}